CANCER TESTIS ANTIGENS IN CANCER IMMUNOTHERAPY
نویسندگان
چکیده
منابع مشابه
Potential of cancer-testis antigens as targets for cancer immunotherapy
Cancer-testis antigens are tumour antigens with limited expression in male germ cells in the testis, ovary and trophoblasts. Recently, their expression has been seen in different types of tumours. Due to the existence of the blood-testis barrier, testis is considered an immune-privileged site; and testis-specific genes, if expressed in cancers, can be immunogenic. For this reason, cancertestis ...
متن کاملCancer-testis antigens: potential targets for cancer immunotherapy.
Cancer-testis antigens are tumor antigens that their expression is almost limited to male germ cells in the testis. Some of cancer-testis antigens are also expressed in the ovary and in trophoblasts. Recently their expression has been seen in different types of tumors. Many pathophysiologic studies suggest that a blood-testis barrier exists in the testis. Because spermatogenesis begins at puber...
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CONTEXT Multiple myeloma (MM) is a B-cell malignancy characterized by monoclonal expansion of abnormal plasma cells in the bone marrow. It accounts for 10% of hematological malignancies. Although patients respond to a wide range of anticancer modalities, relapse occurs in a significant number of the cases. Immunotherapeutic approaches have been evolved to tackle this problem. Cancer-testis anti...
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Recent developments have set the stage for immunotherapy as a supplement to conventional cancer treatment. Consequently, a significant effort is required to further improve efficacy and specificity, particularly the identification of optimal therapeutic targets for clinical testing. Cancer/testis antigens are immunogenic, highly cancer-specific, and frequently expressed in various types of canc...
متن کاملCancer testis antigens
Cancer immunotherapy is a promising field with limited success, also due to lack of tumor-specific targets. In our attempt of exploring novel biomarkers and immunotherapeutic targets against cancer, we have discovered a novel cancer testis antigen, SPAG9, in cancers of different histological origin and demonstrated its potential role in oncogenesis.
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ژورنال
عنوان ژورنال: Siberian journal of oncology
سال: 2017
ISSN: 2312-3168,1814-4861
DOI: 10.21294/1814-4861-2017-16-2-71-81